Cécile Delorme Selected Research

Pyrimidinones

2/2014	Discovery and optimization of pyrimidone indoline amide PI3Kβ inhibitors for the treatment of phosphatase and tensin homologue (PTEN)-deficient cancers.
5/2012	Discovery and optimization of new benzimidazole- and benzoxazole-pyrimidone selective PI3Kβ inhibitors for the treatment of phosphatase and TENsin homologue (PTEN)-deficient cancers.

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Cécile Delorme Research Topics

Disease

3	Tourette Syndrome (Tourette's Syndrome) 03/2022 - 02/2016
3	COVID-19 01/2022 - 01/2021
3	Neoplasms (Cancer) 01/2016 - 05/2012
2	Chorea (Rheumatic Chorea) 01/2021 - 02/2016
1	Dyspnea (Shortness of Breath) 01/2022
1	Parkinson Disease (Parkinson's Disease) 06/2021
1	Brain Diseases (Brain Disorder) 01/2021
1	Delirium 01/2021
1	Dystonia (Limb Dystonia) 01/2021
1	Infections 01/2021
1	Inflammation (Inflammations) 01/2021
1	Liver Diseases (Liver Disease) 01/2021
1	Movement Disorders (Movement Disorder) 01/2021
1	Nervous System Diseases (Neurological Disorders) 01/2021
1	Critical Illness (Critically Ill) 01/2021
1	Renal Insufficiency (Renal Failure) 01/2021
1	Dysphonia (Spastic Dysphonia) 01/2021
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2020
1	Leukoencephalopathies 12/2019
1	Hodgkin Disease (Hodgkin's Disease) 01/2019
1	Polyradiculoneuropathy (Polyradiculoneuritis) 01/2019
1	Chronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP) 12/2018
1	Autoimmune Diseases (Autoimmune Disease) 12/2018
1	Neuroblastoma 01/2017
1	Huntington Disease (Huntington's Disease) 02/2016
1	Melanoma (Melanoma, Malignant) 01/2016
1	Carcinogenesis 05/2012

Drug/Important Bio-Agent (IBA)

2	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2021
2	Protein Isoforms (Isoforms)IBA 01/2016 - 05/2012
2	Phosphotransferases (Kinase)IBA 01/2016 - 05/2012
2	PyrimidinonesIBA 02/2014 - 05/2012
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 02/2014 - 05/2012
2	TensinsIBA 02/2014 - 05/2012
1	fibrin fragment D (D-dimer)IBA 01/2022
1	Apomorphine FDA Link 06/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Biological ProductsIBA 01/2021
1	Hypnotics and Sedatives (Sedatives)IBA 01/2021
1	Rituximab (Mabthera)FDA Link 12/2018
1	Caspase 3 (Caspase-3)IBA 01/2017
1	Proteins (Proteins, Gene)FDA Link 01/2017
1	Dopamine (Intropin)FDA LinkGeneric 01/2017
1	Antipsychotic Agents (Antipsychotics)IBA 02/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2016
1	VemurafenibIBA 01/2016
1	2- (2- (2- methyl- 2,3- dihydroindol- 1- yl)- 2- oxoethyl)- 6- morpholin- 4- yl- 3H- pyrimidin- 4- oneIBA 01/2016
1	AZD 6244IBA 01/2016
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 01/2016
1	Proto-Oncogene Proteins B-rafIBA 01/2016
1	indolineIBA 02/2014
1	AmidesIBA 02/2014
1	BenzoxazolesIBA 05/2012
1	benzimidazoleIBA 05/2012

Therapy/Procedure

4	Deep Brain Stimulation 03/2022 - 02/2016
2	Critical Care (Surgical Intensive Care) 01/2022 - 01/2021
2	Therapeutics 01/2021 - 01/2019
1	Precision Medicine 01/2021
1	Stem Cell Transplantation 12/2019